Quote Originally Posted by mauvebutterfly View Post
Another option might be to only allow players within 2 seats of a player respond or be affected by a card.

Take a 6 player game, for example, the players opposite each other would never be able to target each other with spells or abilities, or cancel those abilities. Once a player is eliminated, people move in closer to fill the gap.

Could make it interesting if in an 8+ player game one player plays a card killing all creatures in play. It would actually only affect 5 players, allowing more distant players an opportunity to beat down the competition.
Since it is online you could also make it so you couldn't see the players that were too far away until they got close enough so you have no idea what to expect.